کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487775 | 1114431 | 2007 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Drug Release from Differently Structured Monoolein/Poloxamer Nanodispersions Studied with Differential Pulse Polarography and Ultrafiltration at Low Pressure
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Drug Release from Differently Structured Monoolein/Poloxamer Nanodispersions Studied with Differential Pulse Polarography and Ultrafiltration at Low Pressure Drug Release from Differently Structured Monoolein/Poloxamer Nanodispersions Studied with Differential Pulse Polarography and Ultrafiltration at Low Pressure](/preview/png/2487775.png)
چکیده انگلیسی
Aqueous colloidal monoolein/poloxamer dispersions are under investigation as drug delivery systems. Depending on the composition and preparation procedure these dispersions may either contain predominantly vesicular particles or nanoparticles of cubic inner structure. To study the influence of ultrastructure on drug release, corresponding dispersions loaded with the model drugs diazepam (two different concentrations) and chloramphenicol were prepared by highâpressure homogenization with or without subsequent heat treatment. The dispersions were characterized with regard to particle size and their ultrastructure was confirmed with small angle Xâray diffractometry. Two techniques with high time resolution, differential pulse polarography (DPP) and ultrafiltration at low pressure were compared for their suitability to monitor rapid release from the dispersions. Instantaneous release was found for both drugs independent on the type of particle structure with the amount of released drug being controlled by the partition coefficient. Both release methods were suitable to monitor the rapid appearance of the releasable drug in the release medium.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 6, June 2007, Pages 1564-1575
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 6, June 2007, Pages 1564-1575
نویسندگان
Karin M. Rosenblatt, Dionysios Douroumis, Heike Bunjes,