کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487822 | 1114435 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of Polymorphic Form, Morphology, and Excipient Interactions on the Dissolution of Carbamazepine Compacts
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Influence of Polymorphic Form, Morphology, and Excipient Interactions on the Dissolution of Carbamazepine Compacts Influence of Polymorphic Form, Morphology, and Excipient Interactions on the Dissolution of Carbamazepine Compacts](/preview/png/2487822.png)
چکیده انگلیسی
To gain a deeper understanding of the behavior of carbamazepine (CBZ) and CBZ dihydrate (DH) compacts during in vitro dissolution tests various factors were investigated: hydrate formation of CBZ, crystal morphology, surface area, and excipient influence. Dissolution tests were performed in three different dissolution media: distilled water, hydroxypropyl methylcellulose (HPMC), and polyethylene glycol (PEG) solutions. For the CBZ compacts, the dissolution rate of CBZ in water was fastest (0.338 mg Lâ1minâ1). With increasing ability of the excipients to inhibit the hydration of CBZ (PEGâ<âHPMC), surprisingly the dissolution rate of CBZ compacts decreased: PEG solution (0.314 mg Lâ1minâ1)â>âHPMC solution (0.257 mg Lâ1minâ1). This implies that DH formation resulted in an apparent increase in the dissolution rate rather than slowing it down. For the DH compacts, the dissolution rate in water (0.055 mg Lâ1 minâ1) was slower than that of PEG and HPMC solutions (0.174 and 0.178 mg Lâ1 minâ1, respectively). The contact angle measurements showed a significantly higher value in water (61.0°) than in PEG and HPMC solutions (44.8° and 43.1°, respectively). Although the dissolution of CBZ and DH compacts in various dissolution media are complex processes, the influence and relative importance of these factors were clearly detected providing better understanding of the dissolution behavior of the drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 3, March 2007, Pages 584-594
Journal: Journal of Pharmaceutical Sciences - Volume 96, Issue 3, March 2007, Pages 584-594
نویسندگان
Fang Tian, Niklas Sandler, Jaakko Aaltonen, Carolin Lang, Dorothy J. Saville, Keith C. Gordon, Clare J. Strachan, Jukka Rantanen, Thomas Rades,