کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487909 | 1114440 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Degradation Rate of Lyophilized Insulin, Exhibiting an Apparent Arrhenius Behavior around Glass Transition Temperature Regardless of Significant Contribution of Molecular Mobility
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Degradation Rate of Lyophilized Insulin, Exhibiting an Apparent Arrhenius Behavior around Glass Transition Temperature Regardless of Significant Contribution of Molecular Mobility Degradation Rate of Lyophilized Insulin, Exhibiting an Apparent Arrhenius Behavior around Glass Transition Temperature Regardless of Significant Contribution of Molecular Mobility](/preview/png/2487909.png)
چکیده انگلیسی
The relative influences of chemical activation energy and molecular mobility in determining chemical reactivity were evaluated for insulin lyophilized with α,β-poly(N-hydroxyethyl)-L-aspartamide (PHEA), and compared with that for insulin lyophilized with trehalose, which had been found to have the ability to decrease the molecular mobility of insulin at low humidity. The ratio of the observed rate constant kobs to the chemical activation energy-controlled rate constant kact (kobs/kact) at glass transition temperature (Tg) was estimated to be approximately 0.6 and 0.8 at 6% RH and 12% RH, respectively, indicating that the degradation rate is significantly affected by molecular mobility at lower humidity conditions. However, these kobs/kact values at Tg were larger than those for the insulin-trehalose system, and changes in the temperature-dependent slope around Tg were less obvious than those for the insulin-trehalose system. Thus, the contribution of molecular mobility to the degradation rate in the insulin-PHEA system appeared to be less intense than that in the insulin-trehalose system. The subtle change in the temperature-dependent slope around Tg observed in the insulin-PHEA system brought about a significant bias in shelf-life estimation when the reaction rate was extrapolated from temperatures above Tg according to the Arrhenius equation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 12, December 2006, Pages 2684-2691
Journal: Journal of Pharmaceutical Sciences - Volume 95, Issue 12, December 2006, Pages 2684-2691
نویسندگان
Sumie Yoshioka, Tamaki Miyazaki, Yukio Aso,