کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2488189 | 1114465 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Polymorphism of a Novel Sodium Ion Channel Blocker
ترجمه فارسی عنوان
پلیمورفیسم مسدود کننده کانال یون سدیم رمان
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
چکیده انگلیسی
2â{[4â(4âFluorophenoxy)phenyl]âmethylene}âhydrazinecarboxamide, a member of the semicarbazone family which has shown potential therapeutic use as anticonvulsants, has been found to exist in two polymorphic forms denoted A and B. In addition to reporting aspects of the physical characterization of both forms, the crystal structure of polymorph A has been determined directly from powder Xâray diffraction data using the Genetic Algorithm technique for structure solution, followed by Rietveld refinement. This structure is compared with that of polymorph B, which was determined previously from single crystal Xâray diffraction data. Knowledge of the crystal structures of the two polymorphs provides the opportunity for establishing structureâproperty relationships. This work further emphasizes the scope and utility of ab initio structure solution from powder Xâray diffraction data in the pharmaceuticals field. © 2003 WileyâLiss, Inc. and the American Pharmacists Association J Pharm Sci 92:2017-2026, 2003
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 92, Issue 10, October 2003, Pages 2017-2026
Journal: Journal of Pharmaceutical Sciences - Volume 92, Issue 10, October 2003, Pages 2017-2026
نویسندگان
Eugene Y. Cheung, Kenneth D.M. Harris, Roy L. Johnston, Kelly L. Hadden, Marek Zakrzewski,