کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2498258 1556738 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin
چکیده انگلیسی

Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25 °C/60% RH) and long-term (5 °C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5 °C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p > 0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5 °C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5 °C.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 11, Issue 5, October 2016, Pages 648–654
نویسندگان
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