کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2498543 | 1556754 | 2014 | 7 صفحه PDF | دانلود رایگان |
Obtaining the target blood pressure level by monotherapy can be challenging currently, especially for the patients who are suffering from other diseases meanwhile. It is demonstrated that a majority of hypertensive patients need two or more antihypertensive drugs to lower their blood pressure effectively. Consequently, fixed-dose which can be defined as that several active agents were combined in single pharmaceutical formulations appears to be a novel and underlying power in overcoming the cardiovascular disease. Based on the analysis of some literature and relative data from FDA, the advantages of fixed-dose combination are elucidated and formulations of common dual, triple-combinations were summarized. Clinical practices proved that fixed-dose combinations had many benefits comparing with single drug and separate agents in terms of effects, convenience, compliance, and costs to a certain extent. From the patients' perspective, the fixed-dose combination therapy will be increasingly utilized in blood pressure control in the future.
Journal: Asian Journal of Pharmaceutical Sciences - Volume 9, Issue 1, February 2014, Pages 1–7