کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2498551 | 1556752 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tablets
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tablets Evaluation of stability and simultaneous determination of fimasartan and amlodipine by a HPLC method in combination tablets](/preview/png/2498551.png)
چکیده انگلیسی
A simple, rapid, accurate, precise and robust HPLC method was developed for the simultaneous determination of fimasartan and amlodipine in tablet dosage form. Furthermore, stability of active ingredients was evaluated under normal and stress conditions. The isocratic elution was accomplished by Nucleosil C18 column (250 mm × 4.6 mm, 5 μm) at 40 °C. The mobile phase consisted of acetonitrile and 0.02 M monopotassium phosphate buffer (pH 2.2) in the ratio of 50:50 (v/v) was eluted at 1.0 ml/min. The eluent was monitored by the UV detector for fimasartan and amlodipine at 237 nm for 8 min, detection time. The validation of HPLC method was carried out in accordance with the ICH guidelines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Asian Journal of Pharmaceutical Sciences - Volume 9, Issue 3, June 2014, Pages 123–128
Journal: Asian Journal of Pharmaceutical Sciences - Volume 9, Issue 3, June 2014, Pages 123–128
نویسندگان
Hyeon Woo Moon, Abid Mehmood Yousaf, Kwan Hyung Cho, Chul Soon Yong, Jong Oh Kim, Han-Gon Choi,