کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2498587 | 1556760 | 2013 | 8 صفحه PDF | دانلود رایگان |

This study is one of the first to focus on the unexpected drug leakage from discoidal recombinant high-density lipoproteins (d-rHDLs) as a consequence of remodeling process, mainly associated with lecithin-cholesterol acyltransferase (LCAT) during their metabolic process. Here, a newly monocholesterylsuccinate (CHS) modified paclitaxel-loaded d-rHDLs (cP-d-rHDLs) were constructed successfully through structural modification, thus aiming to improve the performance of d-rHDLs. And next their in vitro physiochemical properties and pharmacokinetics in Sprague–Dawley rats were elaborately investigated. Collectively our studies demonstrated that cP-d-rHDLs, whose remodeling behaviors were restrained effectively after structural modification, exhibited more excellent and promising properties as novel delivery vehicles for anti-cancer agents.
Journal: Asian Journal of Pharmaceutical Sciences - Volume 8, Issue 1, February 2013, Pages 11–18