کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2498964 1116483 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular mechanisms of liver injury: Apoptosis or necrosis
ترجمه فارسی عنوان
مکانیزم های مولکولی آسیب کبدی: آپوپتوز یا نکروز
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی


• Apoptosis and necrosis are typical pathological features of liver diseases.
• Apoptosis and necrosis represent alternative outcomes of different etiology during liver injury.
• Therapeutic options of liver disease depend on the understanding toward pathogenic mechanisms of different etiology.

Hepatic apoptosis is thought of as a prevalent mechanism in most forms of liver injury. However, the role of hepatic apoptosis is often intermixed with the cellular necrosis. It remains unknown how apoptosis is relevant to the progression of the liver injury. This review summarizes the characteristics of both hepatic apoptosis and necrosis in pathogenesis of liver diseases. Apoptosis and necrosis represent alternative outcomes of different etiology during liver injury. Apoptosis is a main mode of cell death in chronic viral hepatitis, but is intermingled with necrosis in cholestatic livers. Necrosis is the principal type of liver cell killing in acetaminophen-induced hepatotoxicity. Anti-apoptosis as a strategy is beneficial to liver repair response. Therapeutic options of liver disease depend on the understanding toward pathogenic mechanisms of different etiology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental and Toxicologic Pathology - Volume 66, Issue 8, October 2014, Pages 351–356
نویسندگان
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