کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500729 1556893 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interaction of some new 2-(substituted-thio)-quinazolin-4-ones with molybdenum hydroxylases: A pharmacophore prediction
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Interaction of some new 2-(substituted-thio)-quinazolin-4-ones with molybdenum hydroxylases: A pharmacophore prediction
چکیده انگلیسی

BackgroundMolybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases.MethodsTwenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases.Results and conclusionThe tested quinazolines inhibited both xanthine oxidase and aldehyde oxidase enzymes in a competitive pattern with Ki values range of 66–753 μM. Pharmacophore prediction methodology was used to study the structure requirements of those inhibitors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Future Journal of Pharmaceutical Sciences - Volume 1, Issue 2, December 2015, Pages 50–56
نویسندگان
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