کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500810 1557311 2016 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in abuse-deterrent technologies for the delivery of opioids
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Recent advances in abuse-deterrent technologies for the delivery of opioids
چکیده انگلیسی

Over the past decade, the abuse of prescription opioid drugs has become a national health crisis in the United States. Pharmaceutical companies, the Food and Drug Administration, and other government agencies are confronting opioid abuse by developing and commercializing various abuse-deterrent drug delivery technologies. To deter opioid abuse, various strategies including physical barriers, chemical barriers, antagonists, aversive agents, and prodrugs have been investigated. A number of drug products with abuse-deterrent properties have been approved by the FDA over the last six years, while many products and technologies with progressively-improved abuse-deterrence properties are currently being evaluated. This article provides a comprehensive review of the material sciences principles that govern the formulation and processing of a wide range of abuse-deterrent products and technologies.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 510, Issue 1, 20 August 2016, Pages 57–72
نویسندگان
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