کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2500816 | 1557311 | 2016 | 16 صفحه PDF | دانلود رایگان |
This paper demonstrates the application of model-predictive control to a feeding blending unit used in continuous pharmaceutical manufacturing. The goal of this contribution is, on the one hand, to highlight the advantages of the proposed concept compared to conventional PI-controllers, and, on the other hand, to present a step-by-step guide for controller synthesis. The derivation of the required mathematical plant model is given in detail and all the steps required to develop a model-predictive controller are shown. Compared to conventional concepts, the proposed approach allows to conveniently consider constraints (e.g. mass hold-up in the blender) and offers a straightforward, easy to tune controller setup. The concept is implemented in a simulation environment. In order to realize it on a real system, additional aspects (e.g., state estimation, measurement equipment) will have to be investigated.
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Journal: International Journal of Pharmaceutics - Volume 510, Issue 1, 20 August 2016, Pages 100–115