کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2500868 | 1557316 | 2016 | 7 صفحه PDF | دانلود رایگان |
The oxidative stress induced by light exposed gold nanoparticles in some microorganism cells was investigated. Gold nanoparticles are currently used in biomedical and pharmaceutical research. For this study citrate-gold nanoparticles were synthesized in alkaline conditions at constant temperature of 85 °C under magnetic stirring. Equal volumes of such prepared colloidal solution, were exposed to visible light at different wavelengths for 90 min at room temperature. The spectra in the visible and ultraviolet range have revealed an increase in the intensity of the absorption band for gold nanoparticles exposed to light, due to the effect of surface plasmon resonance. Versatility of gold nanoparticles photocatalytic action was shown by means of manipulating wavelengths of incident light, which evidenced differences in the bioeffects induced in cellulolytic fungi − known for their environmental role but also for other applications such as in cosmetics industry. The comparative analysis of fungal response to gold nanoparticle stressors has revealed different enzyme activity and lipid peroxidation when fungi were supplied with gold nanoparticles exposed to different wavelength lights. The activity of catalase and superoxide dismutase were remarkably increased for green light exposure of gold nanoparticles suggesting fungi adaption to increased oxidative stress induced by irradiated particles; increased level of lipid peroxidation was showed by high concentration of malondialdehyde for white light exposed gold particles since antioxidant enzymes were less active.
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Journal: International Journal of Pharmaceutics - Volume 505, Issues 1–2, 30 May 2016, Pages 255–261