کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2501117 | 1557323 | 2016 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying](/preview/png/2501117.png)
Currently, most of the approved protein and peptide-based medicines are delivered via conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent dosing regimen is often necessary because of their short plasma half-lives, causing poor patient compliance (e.g. pain, abscess, etc.), side effects owing to typical peak-valley plasma concentration time profiles, and increased costs. Among many sustained-release formulations poly lactic-co-glycolic acid (PLGA)-based depot microparticle systems may represent one of the most promising approaches to provide protein and peptide drugs with a steady pharmacokinetic/pharmacodynamic profile maintained for a long period. However, the development of PLGA-based microparticle systems is still impeded by lack of easy, fast, effective manufacturing technologies. The aim of this paper is to review recent advances in spray drying, a one-step, continuous microencapsulation process, for manufacturing of PLGA-based depot microparticle systems with a focus on the recent efforts on understanding of the role of nozzle design in the microencapsulation of proteins/peptides, and the effect of critical solvent properties and process parameters on the critical quality attributes of the spray-dried microparticles.
Figure optionsDownload high-quality image (138 K)Download as PowerPoint slide
Journal: International Journal of Pharmaceutics - Volume 498, Issues 1–2, 10 February 2016, Pages 82–95