کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501276 1557331 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fabrication of rectorite-contained nanoparticles for drug delivery with a green and one-step synthesis method
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Fabrication of rectorite-contained nanoparticles for drug delivery with a green and one-step synthesis method
چکیده انگلیسی

The composite nanoparticles (NPs) consisted of quaternized chitosan (QC)/bovine serum albumin (BSA)/rectorite (REC) were prepared successfully just by adding BSA solution into QC-REC nanocomposites solution via electrostatic interactions. The average diameter of NPs increased with the accretion of REC, which was demonstrated with dynamic laser scattering (DLS) and transmission electron microscopy (TEM). The results of small angle X-ray diffraction (SAXRD) and selected area electron diffraction (SAED) demonstrated that the intercalated structure of REC was enlarged with the addition of REC. Besides, it can was proved that the interaction had occurred between QC and REC in NPs with fourier transform infrared (FT-IR) and X-ray photoelectron spectroscopy (XPS). In addition, doxorubicin (DOX) was used to investigate the entrapment efficiency and release pattern in NPs. It turned out to be that the addition of REC could increase the encapsulation efficiency (EE) and loading capacity (LC). The results also exhibited that the drug release in simulated gastric fluid reduced apparently with the addition of REC, which could ensure more DOX released in intestines.

Figure optionsDownload high-quality image (170 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 493, Issues 1–2, 30 September 2015, Pages 426–433
نویسندگان
, , , , , , , ,