کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501384 1557335 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyaluronic acid based micelle for articular delivery of triamcinolone, preparation, in vitro and in vivo evaluation
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Hyaluronic acid based micelle for articular delivery of triamcinolone, preparation, in vitro and in vivo evaluation
چکیده انگلیسی

A novel triamcinolone loaded polymeric micelle was synthesized based on hyaluronic acid and phospholipid for articular delivery. The newly developed micelle was characterized for physicochemical properties including size, zeta potential, differential scanning calorimetry (DSC) analysis and also morphology by means of transmission electron microscopy. The biocompatibility of micelle was explored by histopathological experiment in rat model. Also biological fate of micelle was investigated in rat by means of real time in vivo imaging system. Triamcinolone loaded micelle was in the size range of 186 nm with negative zeta potential charge. Micelles were spherical in shape with core shell like structure. Triamcinolone was released from micelle during 76 h with almost low burst effect. DSC analysis showed the conversion of crystalline triamcinolone from its crystalline state. Histopathological analysis showed no evidence of tissue damage or phagocytic accumulation in knee joint of rat. The real time in vivo imaging analysis suggested at least three days retention time of micellar system in knee joint post injection.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 489, Issues 1–2, 15 July 2015, Pages 218–225
نویسندگان
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