Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters

• Some organic UV-filters have anti-inflammatory properties.
• Benzophenone, octyldimethylPABA and octylmethoxycinnamate display a very marked anti-inflammatory effect up to 390 minutes after application.
• The same phenomenon is observed in the case of commercial sunscreens.

Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence of the anti-inflammatory effect of fourteen preparations, each containing one of the ultraviolet filters authorized by Regulation (CE) No. 1223/2009, and of 10 commercially-available sun products was studied using the phorbol-myristate-acetate test on mice, up to 6 and a half hours after application. We can observe that a benzophenone, oxybenzone, a PABA derivative, octyldimethylPABA and a derivative of cinnamic acid, OMC as well as 3 commercially-available products, display a very marked anti-inflammatory effect at the end of our experimentation phase. The type of effect observed could encourage users to prolong the time that they are exposed to the sun, due to there being no warning signs, namely sunburn.

Persistence of the anti-inflammatory effect observed after application of preparations containing various ultraviolet filters authorized in EU.Figure optionsDownload high-quality image (194 K)Download as PowerPoint slide