کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2501954 1557367 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose
چکیده انگلیسی

TEMPO-mediated surface oxidation of mesoporous highly crystalline Cladophora cellulose was used to introduce negative surface charges onto cellulose nanofibrils without significantly altering other structural characteristics. This enabled the investigation of the influence of mesoporous nanocellulose surface charges on aspirin chemical stability to be conducted. The negative surface charges (carboxylate content 0.44 ± 0.01 mmol/g) introduced on the mesoporous crystalline nanocellulose significantly accelerated aspirin degradation, compared to the starting material which had significantly less surface charge (0.06 ± 0.01 mmol/g). This effect followed from an increased aspirin amorphisation ability in mesopores of the oxidized nanocellulose. These results highlight the importance of surface charges in formulating nanocellulose for drug delivery.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 461, Issues 1–2, 30 January 2014, Pages 74–81
نویسندگان
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