کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502056 1557371 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of permeation enhancers on dynamic mechanical properties of acrylate pressure sensitive adhesives
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Effect of permeation enhancers on dynamic mechanical properties of acrylate pressure sensitive adhesives
چکیده انگلیسی

Physico-chemical properties of permeation enhancers like molecular weight/size, hydrophobicity/hydrophilicity, co-solvency, etc. are necessary during their selection for pharmaceutical product development. Chemical permeation enhancers modulate the viscoelastic properties of pressure sensitive adhesives. The extent of this modulation depends upon the molecular size and branching of the polymeric chains. The functional nature of this branching additionally changes the peel and tack properties of PSA's. Chemical permeation enhancers alone are not able to modify viscoelastic properties of aqueous based PSA's as compared with their solvent based counterparts. These modulated mechanical aspects need to be maintained throughout development of transdermal patch along with other pharmaceutical aspects like drug release and drug stability.

Figure optionsDownload high-quality image (117 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 458, Issue 1, 15 December 2013, Pages 141–147
نویسندگان
, ,