کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502350 1557378 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of capsule-filling machine vibrations on average fill weight
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
The effect of capsule-filling machine vibrations on average fill weight
چکیده انگلیسی

The aim of this paper is to study the effect of the speed of capsule filling and the inherent machine vibrations on fill weight for a dosator-nozzle machine. The results show that increasing speed of capsule filling amplifies the vibration intensity (as measured by Laser Doppler vibrometer) of the machine frame, which leads to powder densification. The mass of the powder (fill weight) collected via the nozzle is significantly larger at a higher capsule filling speed. Therefore, there is a correlation between powder densification under more intense vibrations and larger fill weights. Quality-by Design of powder based products should evaluate the effect of environmental vibrations on material attributes, which in turn may affect product quality.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 454, Issue 1, 15 September 2013, Pages 381–387
نویسندگان
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