کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502504 1557390 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characteristics of sequential targeting of brain glioma for transferrin-modified cisplatin liposome
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Characteristics of sequential targeting of brain glioma for transferrin-modified cisplatin liposome
چکیده انگلیسی

Methods on how to improve the sequential targeting of glioma subsequent to passing of drug through the blood–brain barrier (BBB) have been occasionally reported. However, the characteristics involved are poorly understood. In the present study, cisplatin (Cis) liposome (lipo) was modified with transferrin (Tf) to investigate the characteristics of potential sequential targeting to glioma. In bEnd3/C6 co-culture BBB models, higher transport efficiency across the BBB and cytotoxicity in basal C6 cells induced by Cis-lipo(Tf) than Cis-lipo and Cis-solution, suggest its sequential targeting effect. Interestingly, similar liposomal morphology as that of donor compartment was first demonstrated in the receptor solution of BBB models. Meanwhile, a greater acquisition in the lysosome of bEnd3, distributed sequentially into the nucleus of C6 cells were found for the Cis-lipo(Tf). Pre-incubation of chlorpromazine and Tf inhibited this process, indicating that a clathrin-dependent endocytosis is involved in the transport of Cis-lipo(Tf) across the BBB.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 444, Issues 1–2, 28 February 2013, Pages 1–9
نویسندگان
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