کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502512 1557390 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drug
چکیده انگلیسی

The therapeutic efficacy of lipophilic drugs is commonly restricted by the low systemic exposure after oral administration. In this work, a new delivery system combining the advantages of porous starch and self-assembled nanocarrier was designed to improve the oral absorption of lipophilic drugs. The lipophilic probucol loaded porous starch based self-assembled nano-delivery (PSN) system was developed and characterized. The probucol loaded nanocarrier (PLN) could be formed by self-assembly when PSN was dispersed into the gastrointestinal (GI) fluids. PLN was nanometer-sized particles with narrow size distribution and exhibited good stability in GI fluids. The aqueous solubility of probucol was increased over 50,000-fold by PSN delivery system and the cumulative release of lipophilic probucol was increased over 80% in GI fluids. The distribution of probucol in duodenum, jejunum and ileum was respectively improved 7.17, 15.99 and 33.61-fold by PSN. In particular, the oral bioavailability of probucol from PSN was greatly improved about 9.96-fold than that from free drug suspension and 3.71-fold higher than that from the directed adsorbed probucol loaded porous starch system, which effectively confirmed the high potential of the strategy in enhancing the oral absorption of lipophilic drugs.

A new porous starch based self-assembled nano-delivery system improves the oral absorption of lipophilic drugs in rats.Figure optionsDownload high-quality image (209 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 444, Issues 1–2, 28 February 2013, Pages 162–168
نویسندگان
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