کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2502867 | 1557405 | 2012 | 6 صفحه PDF | دانلود رایگان |
Glycol chitosan (GC)-grafted fullerene (GC-g-C60) conjugates were developed for use in photodynamic therapy of tumor cells. GC-g-C60 was synthesized in anhydrous benzene/dimethylsulfoxide (DMSO) co-solvent via the chemical conjugation of free amine groups of GC to CC double bonds of C60. The GC-g-C60 with 5 × 10−4 C60 molecules per one repeating unit of GC was soluble in water. As C60 molecules conjugated to GC increased to 0.16 molecules per one repeating unit of GC, GC-g-C60 started to form supramolecular assemblies (∼30 nm) stabilized in phosphate buffer saline (PBS, 150 mM, pH 7.4). Upon 670 nm light illumination, photo-responsive properties of GC-g-C60 allowed tremendous singlet oxygen generation in tumor cells for super phototoxicity. GC-g-C60 also showed highly increased tumor accumulation ability for in vivo tumor of KB tumor-bearing nude mice. It is expected that our GC-g-C60 conjugate may be a good candidate for in vivo photodynamic therapy in various malignant tumor cells.
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Journal: International Journal of Pharmaceutics - Volume 431, Issues 1–2, 15 July 2012, Pages 204–209