کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502970 1557407 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Taste masked lipid pellets with enhanced release of hydrophobic active ingredient
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Taste masked lipid pellets with enhanced release of hydrophobic active ingredient
چکیده انگلیسی

Solid lipid extrusion is a suitable technique to produce oral dosage forms with improved taste properties. The design of a lipid formulation for poorly water soluble drugs is a challenge because of the poor dissolution and potential bioavailability problems. In this study, solid lipid extrusion at room temperature was applied for the formulation development of the BCS Class II drug NXP 1210. Powdered hard fat (Witocan® 42/44 mikrofein), glycerol distearate (Precirol® ato 5) and glycerol trimyristate (Dynasan® 114) were investigated as lipid binders. Different amounts of polyvinylalcohol (PVA)–polyethyleneglycol (PEG)-graft copolymer (Kollicoat® IR) and crospovidone (Polyplasdone® Xl-10) were scrutinized as solubilizers. The dissolution profiles depicted a short lag time (about 2 min) and then fast and complete dissolution of NXP 1210 by increasing the amount of crospovidone. The initial release was more delayed with an increased amount of PVA–PEG-graft copolymer. Dissolution rate could also be influenced by changing the lipid binder from pure hard fat into a mixture of hard fat, glycerol distearate and glycerol trimyristate. The formulations are feasible for taste-masked granules or pellets containing poorly soluble drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 429, Issues 1–2, 15 June 2012, Pages 99–103
نویسندگان
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