کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2502988 1557419 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of fenofibrate microemulsion for improved bioavailability
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Design of fenofibrate microemulsion for improved bioavailability
چکیده انگلیسی

The objective of the present study was to formulate a microemulsion system for oral administration to improve the solubility and bioavailability of fenofibrate. Various formulations were prepared using different ratios of oils, surfactants and co-surfactants (S&CoS). Pseudo-ternary phase diagrams were constructed to evaluate the microemulsification existence area. The formulations were characterized by solubility of the drug in the vehicles, mean droplet size, and drug content. The stability was also investigated by store for 3 months under 4 °C, 25 °C and 40 °C and diluted 100 times for 3 days. The optimal formulation consists of 25% Capryol 90, 27.75% Cremophore EL, 9.25% Transcutol P and 38% water (w/w), with a maximum solubility of fenofibrate up to ∼40.96 mg/mL. The microemulsion was physicochemical stable and mean droplet size was about 32.5–41.7 nm. The pharmacokinetic study was performed in dogs and compared with Lipanthy® capsule. The result showed that microemulsion has significantly increased the Cmax and AUC compared to that of Lipanthy® capsule (p < 0.05). The oral bioavailability of fenofibrate microemulsions (FEN-MEs) in ME-3 and ME-4 were 1.63 and 1.30-fold higher than that of the capsule. Our results indicated that the microemulsions could be used as an effective formulation for enhancing the oral bioavailability of fenofibrate.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 420, Issue 2, 28 November 2011, Pages 251–255
نویسندگان
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