کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2502998 | 1557419 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Thermo-responsive shell cross-linked PMMA-b-P(NIPAAm-co-NAS) micelles for drug delivery Thermo-responsive shell cross-linked PMMA-b-P(NIPAAm-co-NAS) micelles for drug delivery](/preview/png/2502998.png)
Thermo-responsive amphiphilic poly(methyl methacrylate)-b-poly(N-isopropylacrylamide-co-N-acryloxysuccinimide) (PMMA-b-P(NIPAAm-co-NAS)) block copolymer was synthesized by successive RAFT polymerizations. The uncross-linked micelles were facilely prepared by directly dissolving the block copolymer in an aqueous medium, and the shell cross-linked (SCL) micelles were further fabricated by the addition of ethylenediamine as a di-functional cross-linker into the micellar solution. Optical absorption measurements showed that the LCST of uncross-linked and cross-linked micelles was 31.0 °C and 40.8 °C, respectively. Transmission electron microscopy (TEM) showed that both uncross-linked and cross-linked micelles exhibited well-defined spherical shape in aqueous phase at room temperature, while the SCL micelles were able to retain the spherical shape with relatively smaller dimension even at 40 °C due to the cross-linked structure. In vitro drug release study demonstrated a slower and more sustained drug release behavior from the SCL micelles at high temperature as compared with the release profile of uncross-linked micelles, indicating the great potential of SCL micelles developed herein as novel smart carriers for controlled drug release.
Thermo-responsive shell cross-linked (SCL) micelles were fabricated based on PMMA-b-P(NIPAAm-co-NAS) copolymer using ethylenediamine as a di-functional cross-linker. Due to the cross-linked structure, the resultant SCL micelles were able to maintain well-defined spherical shape in organic solvent as well as at high temperature. Most importantly, the SCL micelles exhibited more sustained drug release behavior than uncross-linked micelles at high temperature.Figure optionsDownload as PowerPoint slide
Journal: International Journal of Pharmaceutics - Volume 420, Issue 2, 28 November 2011, Pages 333–340