کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503089 1557416 2012 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A model for predicting size distributions delivered from pMDIs with suspended drug
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
A model for predicting size distributions delivered from pMDIs with suspended drug
چکیده انگلیسی

A new model has been developed for predicting size distributions delivered from pressurized metered dose inhalers (pMDIs) that contain suspended drug particles. This model enables the residual particle size distribution to be predicted for a broad range of formulations. It expands on previous models by allowing for polydisperse micronized input drug, multiple suspended drugs, dissolved drug, and dissolved or suspended excipient to be included in the formulation. The model indicates that for most pMDI configurations, the majority of droplets contain no drug or a single drug particle and the residual particle size distribution delivered from the pMDI is essentially equivalent to the size distribution of the micronized drug used in the formulation. However, for pMDIs with a high drug concentration or that use small micronized drug particles, there can be a substantial fraction of the droplets that contain multiple drug particles. The residual particle size distribution obtained from these pMDIs can be substantially larger than the size distribution of the micronized drug. Excellent agreement was observed between size distributions predicted using this model and those obtained from experimental cascade impactor measurements (r2 = 0.97), thus demonstrating the ability of the model to accurately predict the size distributions obtained from suspension pMDIs.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 422, Issues 1–2, 17 January 2012, Pages 101–115
نویسندگان
, , ,