کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2503226 | 1557429 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of sugammadex self-association
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
Sugammadex, a thiolated γCD derivative used as an antagonist of steroidal blockers, was studied with regard to its tendency to self-associate in aqueous solution. Three independent methods – permeation through semi-permeable cellophane membranes, dynamic light scattering, and sedimentation equilibrium analytical ultracentrifugation – were used for this purpose. The results were in agreement with each other and showed no evidence of self-association in a wide sugammadex concentration range from 0.25 to 100 mg/ml.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 413, Issues 1–2, 15 July 2011, Pages 134–139
Journal: International Journal of Pharmaceutics - Volume 413, Issues 1–2, 15 July 2011, Pages 134–139
نویسندگان
Sergey V. Kurkov, Martin Messner, Marjoleine Lucassen, Diels J. van den Dobbelsteen, John den Engelsman, Thorsteinn Loftsson,