کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503309 1557421 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sustained release of 5-fluorouracil by incorporation into sodium carboxymethylcellulose sub-micron fibers
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Sustained release of 5-fluorouracil by incorporation into sodium carboxymethylcellulose sub-micron fibers
چکیده انگلیسی

This work introduces a novel route to the sodium carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug, 5-fluorouracil (5-Fu). The results show that 5-Fu is successfully incorporated into the biocompatible polymer, sodium carboxymethylcellulose (NaCMC)-based fibers with good stability, desired drug loading content and 100% entrapment efficiency. Furthermore, the drug release rate of the as-prepared drug-loaded fibers could be well controlled. The drug release behavior of the 5-Fu-loaded NaCMC fibers shows a diffusion mechanism, obeying Ritger–Peppas kinetics model. The drug release behavior of the as-prepared products demonstrates their promising application in drug delivery system.

On the carboxymethylcellulose sub-micron fibers loaded with hydrophilic anticancer drug for the use in drug delivery system.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 419, Issues 1–2, 31 October 2011, Pages 240–246
نویسندگان
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