کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503384 1557428 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drug targeting to inflammation: Studies on antioxidant surface loaded diclofenac liposomes
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Drug targeting to inflammation: Studies on antioxidant surface loaded diclofenac liposomes
چکیده انگلیسی

Inflammation is associated with enhanced vascular permeability, production of inflammatory markers and over production of reactive oxygen species (ROS) with depletion of endogenous antioxidants. Several drug targeting approaches to inflammation taking clues from these events have been evolved. Surprisingly, a drug targeting approach utilizing abundant oxidative stress at inflammatory site has not been followed. Antioxidant surface loaded liposomes might preferentially localize at inflammatory sites via redox interaction where at high level of ROS exist. The present study was focused to investigate the role of antioxidant as a targeting ligand on the surface of liposome employing rat granuloma air pouch model of inflammation. We developed conventional and antioxidant loaded diclofenac (DFS) liposomes (co-enzyme Q10 and ascorbyl palmitate) for i.v. administration and characterized for vesicle size, zeta potential and percent entrapment. In vivo drug targeting studies showed an increase in AUC, therapeutic availability of DFS in air pouch fluid (APF) and APF/serum DFS concentration ratios from antioxidant loaded liposomes compared to conventional liposomes and drug solution. The promising results suggest the role of antioxidant as a possible ligand in drug targeting to a site where at abundant ROS exist.

The drug targeting potential of prepared antioxidant surface loaded diclofenac liposomes was evaluated in air pouch induced rats. The results envisage better targeting potential for antioxidant surface loaded liposomes to the inflammatory site assessed by measuring the diclofenac content in air pouch fluid.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 414, Issues 1–2, 29 July 2011, Pages 179–185
نویسندگان
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