کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503457 1557426 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Homogeneous diffusion layer model of dissolution incorporating the initial transient phase
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Homogeneous diffusion layer model of dissolution incorporating the initial transient phase
چکیده انگلیسی

Purpose of this paper is to describe characteristic features of dissolution data by using homogeneous model of dissolution with initial transient phase. To achieve the goal we consider a random lag time before the homogeneous phase of the dissolution begins. The resulting dissolution profiles are characterized by sigmoidal shape commonly observed in empirical dissolution data. Furthermore, probability distribution of repeated measurements at fixed time is deduced from the model and function describing variability of the data in dependency on time is proposed. Three examples with normal, exponential and gamma probability distribution of the lag time are presented. All the models are pairwise compared with the Weibull function with high similarity between them. The result offers an alternative interpretation for the frequently found fit of the Weibull model to experimental data.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 416, Issue 1, 15 September 2011, Pages 35–42
نویسندگان
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