کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503488 1557426 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of receptor-based tumor imaging agent: 99mTc-folate-glucaric acid
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of receptor-based tumor imaging agent: 99mTc-folate-glucaric acid
چکیده انگلیسی

The aim of the present study was to prepare 99mTc-folate-glucaric acid and investigate the radiopharmaceutical potential for tumors imaging that over express folate receptor. Folate-glucaric acid was synthesized and the synthesized folate conjugate was confirmed with 1H NMR and LC–MS/MS methods. Folate-glucaric acid was labeled with 99mTc, and its radiolabelling efficiency was found as 96 ± 2.0%. Biodistribution study of 99mTc-folate-glucaric acid was carried out in vivo using two groups of female Albino Wistar rats: folate receptor (FR) saturated and unsaturated. Biodistribution study showed that 99mTc-folate-glucaric acid indicated high uptake in folate receptor rich tissues such as breast, ovary and uterus. Therefore, 99mTc-folate-glucaric acid shows good radiolabeling and biodistribution in FR organs, the radiolabeled conjugate is a reason potentially useful radiopharmaceutical for detection of FR-positive tumors.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 416, Issue 1, 15 September 2011, Pages 288–292
نویسندگان
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