کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2503593 1557433 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physical–chemical assessment of di-(2-ethylhexyl)-phthalate leakage from poly(vinyl chloride) endotracheal tubes after application in high risk newborns
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Physical–chemical assessment of di-(2-ethylhexyl)-phthalate leakage from poly(vinyl chloride) endotracheal tubes after application in high risk newborns
چکیده انگلیسی

Poly(vinyl chloride) (PVC) is extensively used in the production of medical devices including endotracheal tubes. In order to make PVC flexible extensive quantities of plasticizers are added to the virgin matrix and among these, di-(2-ethylhexyl)-phthalate (DEHP) is the most used in PVC medical devices. DEHP is not covalently bound to PVC and during the use of medical devices, it tends to migrate out and accumulate in tissue.To the best of our knowledge, limited literature data are available on the DEHP release from PVC medical devices as a consequence of applications in humans.Aim of the present study was to verify through a physical–chemical characterization the occurrence of DEHP leakage from endotracheal tubes and to determine the correlation between the leaching of the plasticizer and the time of intubation of the tubes in high risk newborns. Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC) and High-Performance Liquid Chromatography (HPLC) analyses were performed and the results show the effective release of DEHP from tubes. Moreover the study reveals that the release of DEHP occurs within the first 24 h of employments of the tubes.

The study investigates the occurrence of di-(2-ethylhexyl)-phthalate (DEHP) release from endotracheal tubes after their application in high risk newborns.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 409, Issues 1–2, 16 May 2011, Pages 57–61
نویسندگان
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