کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2503615 | 1557433 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: PEGylated thermo-sensitive poly(amidoamine) dendritic drug delivery systems PEGylated thermo-sensitive poly(amidoamine) dendritic drug delivery systems](/preview/png/2503615.png)
Thermo-sensitive dendrimers hold promise in various biomedical and pharmaceutical applications due to their stimuli-responsive properties. However, for such systems there are still certain unaddressed issues e.g. the undesired toxicity, immunogenicity and short blood circulation time. PEGylation is a potential approach to solve these above problems. The aims of this study were to engineer PEGylated thermo-sensitive dendritic derivatives and to investigate their temperature sensitivity and drug release behaviour therein. Linear poly(N-isopropylacrylamide) (PNIPAAm) and methoxy poly(ethylene glycol) (MPEG) were attached to the surface of polyamidoamine (PAMAM) dendrimers to generate PAMAM–g–PNIPAAm and PAMAM–g–PNIPAAm–co–PEG. PAMAM–g–PNIPAAm exhibited the lowest critical solution temperature (LCST) of ca. 32 °C, whereas PAMAM–g–PNIPAAm–co–PEG showed a LCST of ca. 35 °C. Indomethacin was used as a model molecule to examine the drug release profiles from both types of dendritic polymers. Results showed that such thermo-sensitive PAMAM derivatives could manipulate drug release simply by controlling the temperature above or below the LCST. At 37 °C a prolonged drug release was obtained for both systems with less than 30% of drug was released over 12 h, whilst the release rate is much faster at 30 °C and ca. 90% of drug was released over 12 h. The results obtained suggest that these thermo-sensitive PAMAM derivatives could be potential drug delivery systems to achieve controlled drug release.
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Journal: International Journal of Pharmaceutics - Volume 409, Issues 1–2, 16 May 2011, Pages 229–236