کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2503798 | 1557442 | 2010 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Insight into glycyrrhetinic acid: The role of the hydroxyl group on liver targeting Insight into glycyrrhetinic acid: The role of the hydroxyl group on liver targeting](/preview/png/2503798.png)
Two kinds of glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles (CTS/PEG-GA NPs) were prepared by an ionic gelation process in which the liver targeting ligand glycyrrhetinic acid (GA) was introduced into the nanoparticles at the C30-carboxyl group (CTS/PEG-GA(c) NPs) or the C3-hydroxyl group (CTS/PEG-GA(h) NPs). Their characteristics, especially their ability to target the liver, were compared. The results showed that both the CTS/PEG-GA(c) NPs and the CTS/PEG-GA(h) NPs are remarkably targeted to the liver. The accumulation in the liver is 51.3% and 56.5% of the injected dose for the CTS/PEG-GA(c)4.60% NPs (the subscript number denotes the GA content as weight percent in nanoparticles) and the CTS/PEG-GA(h)4.57% NPs at 3 h after injection, respectively. This is nearly 2.6–2.8 times higher than that obtained with the CTS/PEG NPs. According to our results, there is no significant difference between the CTS/PEG-GA(c) NPs and the CTS/PEG-GA(h) NPs in their ability to target the liver, when they were formed under identical conditions. This indicated that the C3-hydroxyl group in GA has little influence on the targeting ability.
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Journal: International Journal of Pharmaceutics - Volume 400, Issues 1–2, 15 November 2010, Pages 153–157