کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2503978 | 1557447 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction of acyclovir and its squalenoyl–acyclovir prodrug with DMPC in monolayers at the air/water interface
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Acyclovir has been conjugated to the acyclic isoprenoid chain of squalene to form the squalenoyl–acyclovir prodrug. Its interaction with biomembrane models constituted by dimyristoylphosphatidylcholine (DMPC) monolayers has been studied by employing the Langmuir–Blodgett technique. The aim of the work was to gain information on the interaction of these compounds with phospholipid membranes.DMPC/acyclovir or squalenoyl–acyclovir prodrug mixed monolayers have been prepared at increasing molar fractions of the compound and the isotherm mean molecular area/surface pressure has been registered at 10 and 37 °C. Results reveal that the squalenoyl moiety enhances the affinity of acyclovir for the biomembrane model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 395, Issues 1–2, 16 August 2010, Pages 167–173
Journal: International Journal of Pharmaceutics - Volume 395, Issues 1–2, 16 August 2010, Pages 167–173
نویسندگان
Maria Grazia Sarpietro, Flavio Rocco, Dorotea Micieli, Sara Ottimo, Maurizio Ceruti, Francesco Castelli,