کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504099 1557451 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Construction and in vitro characterization of an optimized porosity-enabled amalgamated matrix for sustained transbuccal drug delivery
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Construction and in vitro characterization of an optimized porosity-enabled amalgamated matrix for sustained transbuccal drug delivery
چکیده انگلیسی

This research focused on constructing and characterizing an optimized porosity-enabled amalgamated matrix (P-EAM) for sustained transbuccal drug delivery. An interphase, co-particulate, co-solvent, homogenization technique and lyophilization guided through a Box–Behnken experimental design was employed in the fabrication, characterization and optimization of 15 P-EAMs. The effects of varying factor levels on the characteristic in vitro physicochemical performances of the P-EAMs were explored. Formulations had an average weight of 128.44 ± 3.48 mg with a dimensional size of 8 mm by 5 mm. Surface morphology showed varieties of pore structures, widespread distributions and uneven interconnectors. Satisfactory drug-loading was achieved (53.14 ± 2.19–99.02 ± 0.74%). Overall amount of drug released in 8 h was measured by the MDT50% value which ranged between 22.50 and 225.00 min. Formulation demonstrated significant levels of ex vivo bioadhesive strength measured as detachment force (Fdet = 0.964 ± 0.015 to 1.042 ± 0.025 N) and work of adhesion (ωadh = 0.0014 ± 0.00005 to 0.0028 ± 0.00008 J). The potential of the P-EAMs to initiate and sustain ex vivo transbuccal permeation of drug was shown and measured as a cumulative value of between 25.02 ± 0.85 and 82.21 ± 0.57% in 8 h. Formulations were mesoporous in nature with pore sizes ranging from 40 to 100 Å characterized by the presence of interconnectors. Statistical constraints were simultaneously set to obtain levels of independent variables that optimized the P-EAM formulation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 391, Issues 1–2, 31 May 2010, Pages 79–89
نویسندگان
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