کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504400 1557455 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Measurement and prediction of solubilities of active pharmaceutical ingredients
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Measurement and prediction of solubilities of active pharmaceutical ingredients
چکیده انگلیسی

Solubilities of 2-acetoxy benzoic acid (aspirin), N-acetyl-p-aminophenol (paracetamol) and 2-(p-isobutylphenyl)propionic acid (ibuprofen) have been measured in various solvents and compared with published and predicted data. For the prediction besides the two group contribution models UNIFAC and modified UNIFAC (Dortmund) the quantum chemical approach COSMO-RS (Ol) was used. Additionally melting temperatures and heats of fusion for 2-acetoxy benzoic acid, N-acetyl-p-aminophenol and 2-(p-isobutylphenyl)propionic acid required for the calculations have been determined by differential scanning calorimetry.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 388, Issues 1–2, 30 March 2010, Pages 73–81
نویسندگان
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