کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504423 1557455 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Silk fibroin nanoparticles for cellular uptake and control release
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Silk fibroin nanoparticles for cellular uptake and control release
چکیده انگلیسی

Silk nanoparticles were prepared from silk fibroin solutions of domesticated Bombyx mori and tropical tasar silkworm Antheraea mylitta and investigated in respect to its particle size, surface charge, stability and morphology along with its cellular uptake and release of growth factors. The nanoparticles were stable, spherical, negatively charged, 150–170 nm in average diameter and exhibited mostly Silk II (β-sheet) structure and did not impose any overt toxicity. Cellular uptake studies showed the accumulation of fluorescence isothiocyanate conjugated silk nanoparticles in the cytosol of murine squamous cell carcinoma cells. In vitro VEGF release from the nanoparticles showed a significantly sustained release over 3 weeks, signifying the potential application as a growth factor delivery system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 388, Issues 1–2, 30 March 2010, Pages 242–250
نویسندگان
, , , , ,