کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504449 1557462 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Influence of the composition of glycerides on the solid-state behaviour and the dissolution profiles of solid lipid extrudates
چکیده انگلیسی

A monoacid triglyceride and a partial glyceride were extruded below their melting ranges alone and together in different mixture ratios to investigate the influence of the chemical composition of the lipid matrix on the solid-state properties and dissolution characteristics. The partial glyceride exhibits a faster release of the drug compared to the triglyceride due to its surfactant properties. The lipid mixtures show rather complex solid-state behaviour and hence unexpected dissolution characteristics. Adding 10% (w/w) partial glyceride to a triglyceride matrix led to increased incidence of the unstable α-form of the triglyceride leading to recrystallization of the stable β-form over time which causes fractal structures on the extrudate surface which decrease the dissolution rate. Adding 50% (w/w) partial glyceride to the triglyceride matrix also results in tristearin α-formation subsequently followed by recrystallization to the β-form. But as 50% of the matrix consists of the partial glyceride the dissolution rate was faster than the rate obtained by pure triglyceride or the 9 + 1 (w/w) mixture of triglyceride and partial glyceride. The results of this study help in understanding the complex solid-state behaviour of solid lipid extrudates with different composition and to manufacture suitable lipid-based oral dosage forms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 381, Issue 2, 3 November 2009, Pages 184–191
نویسندگان
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