کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504636 1557465 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amphiphilic perfluoroalkyl carbohydrates as new tools for liver imaging
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Amphiphilic perfluoroalkyl carbohydrates as new tools for liver imaging
چکیده انگلیسی

The synthesis of three molecules containing a fluorocarbon chain (either C6F13, C8F17 or C10F21), a sugar moiety (derived from lactobionic acid) and a chelate (derived from DTPA) is reported. These molecules (C6F13-Gal-DTPA, C8F17-Gal-DTPA or C10F21-Gal-DTPA) have been dispersed in water and their critical micellar concentration (CMC) as well as their size were determined. Their interaction with serum was weak as evaluated by time resolved fluorimetry of europium complexes. The presence of sugar on the surface of the nanoparticles was confirmed by the agglutination test using ricin. Conditions of pH and concentrations were optimised for in vivo studies. Finally, the nanoparticles formed with C10F21-Gal-DTPA have been complexed with 99mTc and injected to rats in order to follow their biodistribution by scintigraphy while following their stability by transmission electronic microscopy. A majority of the compound was found in the liver post-bolus injection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 379, Issue 2, 11 September 2009, Pages 301–308
نویسندگان
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