کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504653 1557473 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Critical evaluation of cadexomer-iodine ointment and povidone-iodine sugar ointment
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Critical evaluation of cadexomer-iodine ointment and povidone-iodine sugar ointment
چکیده انگلیسی

Topical iodine forms are used for infected and necrotic pressure ulcers. Despite antimicrobial advantages several potential disadvantages were observed with controversial results. To clarify the controversy, the reactivity of povidone-iodine (PI) sugar ointment and cadexomer-iodine (CI) ointment toward biological components was investigated. l-Tyrosine as a component of proteins and egg lecithin as a component of lipid membranes were reacted with forms of iodine. Furthermore, water absorption abilities of ointments were investigated. The reactions of PI sugar ointment and CI ointment with l-tyrosine were reversely dependent on iodine concentrations. CI ointment reacted with lecithin in an iodine concentration dependent manner, while PI sugar ointment reacted with lecithin in an iodine concentration independent steady manner. However, at the clinically relevant iodine concentration (0.1, w/v%) PI sugar ointment reacted efficiently with l-tyrosine and less efficiently with lecithin, while CI ointment reacted efficiently with lecithin and less efficiently with l-tyrosine. Water absorption rate constant was 29.9 mg/cm2/min0.5 for PI sugar ointment and 15.3 for CI ointment. Water absorption capacity per weight over 24 h was 76% for PI sugar ointment and 26% for CI ointment. These results suggest that PI sugar ointment and CI ointment have different characteristics for iodine reactivity and water absorption.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 372, Issues 1–2, 8 May 2009, Pages 85–90
نویسندگان
, , ,