کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504688 1557467 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Levitated single-droplet drying: Case study with itraconazole dried in binary organic solvent mixtures
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Levitated single-droplet drying: Case study with itraconazole dried in binary organic solvent mixtures
چکیده انگلیسی

The objective of this case study of the single-droplet drying of two itraconazole/polymer formulations was to determine how the solvent system influences drying rate and dried particle morphology. A clear dual functionality of the two solutes could be identified. The polymeric component (PVP or HPMC) determined drying rate, whereas the drug determined end particle morphology. This could be related to solubilities of the two components in the binary solvent mixtures used. The formulation of a surface skin early on in drying only occurred with HPMC and strongly influenced drying rate but not dried particle morphology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 378, Issues 1–2, 13 August 2009, Pages 116–121
نویسندگان
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