کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2504692 1557467 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simulation of oral absorption using classical nucleation theory
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
A simulation of oral absorption using classical nucleation theory
چکیده انگلیسی

The purpose of the present study was to investigate the applicability of the classical nucleation theory (CNT) for oral absorption simulation. The CNT was used to simulate the precipitation of low solubility basic compounds in the fasted state simulated intestinal fluid. The infusion–precipitation experiment data reported by Kostewicz et al. [Kostewicz, E.S., Wunderlich, M., Brauns, U., Becker, R., Bock, T., Dressman, J.B., 2004. Predicting the precipitation of poorly soluble weak bases upon entry in the small intestine. J. Pharm. Pharmacol. 56, 43–51] was used for validation. The surface tension of a drug and a pre-exponential factor were obtained by fitting to the experimental data. The CNT adequately simulated the precipitation characteristics of experimental data such as the increase of the precipitation rate and less sensitivity of maximum concentration by the increase of infusion rate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 378, Issues 1–2, 13 August 2009, Pages 142–145
نویسندگان
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