کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2504943 | 1557480 | 2009 | 8 صفحه PDF | دانلود رایگان |
Salting-out effects were utilized for developing a multiparticulate system balancing numbness masking and high bioavailability. A “salting-out taste-masking system” consisting of a drug core containing acetaminophen as a model drug, a salting-out layer containing sodium carbonate (Na2CO3) and hydroxypropylmethylcellulose (HPMC), and a water-penetration-control layer consisting of cetanol was designed and prepared. The system successfully generated a long lag time while achieving immediate drug release. In the system, the Na2CO3 release rate was slower and the lag time was longer than when the water-penetration-control layer was not present. During the release of Na2CO3 from the system, the release of HPMC and drug was suppressed. These results indicated that the water-penetration-control layer maintained a high concentration of Na2CO3, prevented HPMC's dissolution, and generated a long lag time of drug release. The system generated longer lag time and released drug more immediately than formulation containing the water-penetration-control layer of same thickness without the salting-out layers. These results indicated the salting-out layers were necessary for obtain a long lag time and subsequent immediate drug release. This novel taste-masking system has the potential to be a useful multiparticulate dosage form for effective, safe, and user-friendly drug therapy.
Journal: International Journal of Pharmaceutics - Volume 365, Issues 1–2, 5 January 2009, Pages 81–88