کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2504975 | 1557477 | 2009 | 7 صفحه PDF | دانلود رایگان |
In this study we investigated the correlations between the single crystal structure, the crystal habit and morphology, and surface energetics of an investigational pharmaceutical compound. Crystal structures of both the anhydrous form (Form A) and monohydrate form (Form B) have been solved from single crystal X-ray analysis. The external morphology of Form A solid was predicted by molecular modeling using attachment energies to be thick plate-like with two dominant faces (1 0 0) and (0 0 2). The external morphology of Form B was predicted to be needle-like with a dominant face (1 0 1¯). The predicted morphologies were confirmed by optical micrographs and the Miller indices of the dominant faces were complemented by X-ray powder diffraction (XRPD) method. Contact angle measurements showed that the anhydrous form has better wettability as predicted from crystal structure and morphology.
Journal: International Journal of Pharmaceutics - Volume 368, Issues 1–2, 23 February 2009, Pages 76–82