کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2505383 | 1557488 | 2008 | 7 صفحه PDF | دانلود رایگان |
The purpose of the study was to examine the suitability of the Spraytec® laser diffraction technique for measuring the size distribution of aerosol particles generated from dry powder inhalators. A range of formulations with different dispersion properties were produced by spray-drying. The percentage of particles below 5.0 μm of these formulations was measured by laser diffraction (Mastersizer® 2000 and Spraytec®) and inertial impaction (MsLI and NGI) using various inhaler devices and at different flow rates between 30 and 100 l/min. Linear relationships and correlations (R2 > 0.9) existed between the results obtained from, on one hand, the Mastersizer® 2000 and the Spraytec®, and, on the other hand, the MsLI and the Spraytec® regardless of flow rates and inhaler devices. The Spraytec® could be a reliable technique for the development, evaluation and quality control of dry powder aerosol formulations.
Journal: International Journal of Pharmaceutics - Volume 358, Issues 1–2, 24 June 2008, Pages 75–81