کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505489 1557494 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Simulated neonatal exposure to DEHP and MEHP from PVC enteral nutrition products
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Simulated neonatal exposure to DEHP and MEHP from PVC enteral nutrition products
چکیده انگلیسی

The leaching of di(2-ethylhexyl)phthalate (DEHP) and mono(2-ethylhexyl)phthalate (MEHP) from medical products made of polyvinyl-chloride (PVC) to enteral nutrition (EN) for neonatal patients was determined in a simulated study. The study simulated a typical case of EN administration to a neonatal patient (body weight, 3 kg) in a neonatal care unit (temperature, 25 °C); the medical products used were an irrigator and catheter containing DEHP (9.1–31.8%, w/w) as a plasticizer. The worst-case daily exposures of the neonatal patient to DEHP and MEHP by the administration of EN were estimated to be 148 and 3.72 μg/(kg day), respectively, as assessed from the levels of these compounds leaching from the medical products to the EN. The use of DEHP-free medical products reduced the exposure of DEHP and MEHP to the minimum levels contained in the EN at preparation. A transition to DEHP-free medical products for neonatal patients would be effective in reducing the exposure of neonatal patients to DEHP via EN administration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 352, Issues 1–2, 20 March 2008, Pages 139–145
نویسندگان
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