کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2505617 | 1557495 | 2008 | 5 صفحه PDF | دانلود رایگان |
The intestinal absorptive characteristics of ginkgolide B were investigated. The Caco-2 cells and the in situ closed loop were used as models of the intestinal mucosa to assess transepithelial transport of ginkgolide B. The determination of ginkgolide B was performed by HPLC–MS. In the Caco-2 cells, the absorptive transepithelial transport of ginkgolide B was pH dependent and the transport was enhanced at weakly acidic pH on the apical side. No concentration dependence and saturation were observed for the absorptive transport of ginkgolide B at concentrations up to 50 μM. In the in situ closed loop, the absorption of ginkgolide B was intestinal segment-selective. The results indicate that the intestinal absorption of ginkgolide B in the upper intestine was significantly higher than that in the lower intestine.
Journal: International Journal of Pharmaceutics - Volume 351, Issues 1–2, 3 March 2008, Pages 31–35