کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2505682 1557493 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs
چکیده انگلیسی

In this work, a hydrogel-thickened nanoemulsion system (HTN) with powerful permeation ability, good stability and suitable viscosity was investigated for topical delivery of active molecules. HTN was prepared to deliver an oily mixture of 5% camphor, 5% menthol and 5% methyl salicylate for topical therapy of arthritis, minor joint and muscle pain using soybean oil as the oil phase, soybean lecithin, Tween 80 and poloxamer 407 as the surfactants, propylene glycol as the cosurfactant, carbomer 940 as a thickening agent. The HTN system was found to combine the o/w microstructure of nanoemulsion with the gel network of hydrogel and had a suitable viscosity of 133.2 Pa S. The system had small average diameters and good long-term stability. The abilities of HTN to deliver the high amounts of camphor, menthol and methyl salicylate were evaluated using the in vitro permeation studies. The permeation rates of camphor, menthol and methyl salicylate from the optimal HTN formulation were 138.0 ± 6.5, 63.6 ± 3.3, 53.8 ± 3.2 μg cm−2 h−1 and showed the significant advantages over the control gel. The HTN with good stability and powerful permeation enhancing ability and suitable viscosity might be a promising prospective carrier for topical delivery of lipophilic drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 353, Issues 1–2, 2 April 2008, Pages 270–276
نویسندگان
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